Management and treatment of chronic hepatitis B virus infection in HIV positive and negative patients: The EPIB 2008 study

Background & Aims To compare the management and the virological and serological efficacy of treatments for chronic hepatitis B (CHB) in HIV positive and negative patients. Methods Two hundred and forty-six HIV positive and 205 HIV negative consecutive patients with past or present CHB, seen in October 2008 in participating departments, were included in a multicenter study. All the data were retrospectively collected from the first visit to October 2008 through a standardized questionnaire. Results Compared to HIV negative patients, HIV positive patients more often presented positive HBeAg (46.4% vs. 32.8%, p =0.01), HBV genotype A (54.8% vs. 17.1%, p p =0.0002) or HDV (12.6% vs. 2.9%, p =0.04). HIV positive patients were more often on HBV therapy (92.7% vs. 57.1%, p p Conclusions The assessment of CHB and the efficacy of HBV therapy have improved in HIV positive patients. HIV infection did not have a negative impact on the likelihood of HBV therapeutic success.