DEVELOPMENT OF DERIVATIVE SPECTROSCOPY METHOD FOR THE SIMULTANEOUS DETERMINATION OF ROSUVASTATIN CALCIUM AND ASPIRIN IN TABLET

A specific, rapid and simple UV spectrophotometric method with good sensitivity was developed and validated for the simultaneous quantification of Rosuvastatin calcium and aspirin in standard solutions and tablets. The method employed solving of simultaneous equations based on the measurement of absorbance maxima at 340 and 240 nm, for Rosuvastatin calcium and aspirin, respectively. The calibration curve was linear for both drugs in a concentration range of 3--18(μg/ml) and 2-12(μg/ml). It can be concluded from the results that present method for the simultaneous determination of Rosuvastatin calcium and aspirin in tablets is specific, rapid and simple with good sensitivity. This analytical method is also applicable in ordinary laboratories also. It can also be adopted for quality control tests for these drugs in tablets.