Association of genotypes of carcinogen-metabolizing enzymes and smoking status with bladder cancer in a Japanese population

Objectives Arylamines are considered to be the primary causative agent of bladder cancer in tobacco smokers. To test the hypothesis that variation in the genes that metabolize tobacco carcinogens contribute to bladder cancer, we examined the effects of single nucleotide polymorphisms in the genes of four key enzymes: cytochrome P4501A2, N-acetyltransferase (NAT) 2, sulfotransferase1A1, and UDP-glucuronosyltransferase (UGT) 2B7.