The effect of sleep restriction and psychological load on the diurnal metabolic changes in tryptamine-related compounds in human urine

Objective The effect of a severely stressful situation (sleep restriction and psychological load) on the diurnal changes in novel tryptamine-related compounds (hydroxydiacetyltryptamine, sulphatoxymelatonin, and dihydromelatonin) was evaluated in human subjects for 16 days.