Advances on Toxicological Mechanism of AhR Pathway and Early Biomonitoring of Persistent Organic Pollutants (POPs) in Aquatic Animals

With the development of industry and agriculture, the case of cancer is incresing gradually in the last thirty years. Considerable part of the cases are caused by persistent organic pollutants (POPs) and some of them belong to the environmental endocrine disruptors. POPs are ubiquitous in the environment, especilly in the aquatic ecosystem which has aroused the extensive attention of the world. The mechanism of POPs toxicology is very complicated, but it is mainly mediated by the aryl hydrocarbon receptor (AhR) pathway in aquatic animals. The overall goal of this review paper is to highlight the toxicological mechanism of AhR pathway that may contribute to a more holistic understanding of each AhR pathway gene behavior in the toxicological process, as well as the early biomonitoring methods of POPs in aquatic animals. Finally, we propose some perspectives for future toxicological mechhanism research of interest.