Inhibitory effect of prostaglandin E1 on laurate-induced peripheral vascular occlusive sequelae in rabbits : optimized topical formulation with β-cyclodextrin derivative and penetration enhancer HPE-101

Prostaglandin E 1 (PGE 1 ) and its inclusion complexes with β-cyclodextrin (β-CyD) and O-carboxymethyl-O-ethyl-β-cyclodextrin (CME-β-CyD) were made as topical preparations. The PGE 1 preparations, when applied with a penetration enhancer, 1-[2-(decylthio)ethyl]azacyclopentane-2-one (HPE-101), markedly increased the regional blood flow in the ear of rabbits and were longer acting than when administered by the intravenous route