Synthesis, characterization, and hypoglycemic activity of 3-(arylsulfonyl)spiroimidazolidine-2,4-diones
2012
Spiroimidazolidine-2,4-diones were prepared from methylcyclohexanones by the Bucherer-Bergs reac- tion. Synthesis of the target 3-(arylsulfonyl)spiroimidaz- olidine-2,4-diones was achieved by reaction of arylsulfonyl chlorides with corresponding spiroimidazolidine-2,4-diones. The synthesis was confirmed by spectroanalytical techniques and the crystal structure of 3-(4-methoxyphenylsulfonyl)-6- methyl-1,3-diazaspiro(4.5)decane-2,4-dione, and the purity was checked by GC-MS analysis. The in-vivo hypoglycemic potential of 6-methyl-, 7-methyl-, and 8-methyl-3-(4-methyl- phenylsulfonyl)-1,3-diazaspiro(4.5)decane-2,4-dione was investigated on male albino rats. The screened compounds were found to have excellent hypoglycemic activity. 6-Methyl-3-(4-methylphenylsulfonyl)-1,3-diazaspiro(4.5) decane-2,4-dione was found highly active, reducing the blood glucose level by 60.79% compared with 41.60% by the standard (glipizide) at a dose level of 100 mg/kg of the mice body weight. The 8-methyl isomer was also more potent than the standard, with 48.56% reduction in blood glucose level.
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
19
References
11
Citations
NaN
KQI