Synthesis and antiviral activity of phosphonium salts

As a further step in our investigations [i] in the present work we synthesized and studied the ability of alkyl(aryl)phosphonium salts to suppress the reproduction of virus A/Leningrad 34/72 (H3 No. 2). The phosphonium salts were obtained by reacting triphenyl, tris(2cyanoethyl)-, diphenylmethylphosphine with halogen alkines (compounds I-XX, XXIV) or by reacting tertiary phosphines with alkylidenemalonodinitriles in the presence of HCI (compounds XXI-XXIII).