Dosimetric Evaluation of Intensity Modulated Radiotherapy and 4-Field 3-D Conformal Radiotherapy in Prostate Cancer Treatment
2013
Objective: The purpose of this dosimetric study is the targeted dose homogeneity and critical organ dose comparison of 7-field Intensity Modulated Radiotherapy (IMRT) and 3-D 4-field conformal radiotherapy. Study Design: Cross sectional study. Material and Methods: Twenty patients with low and moderate risk prostate cancer treated at Gulhane Military Medical School Radiation Oncology Department between January 2009 and December 2009 are included in this study. Two seperate dosimetric plans both for 7-field IMRT and 3D-CRT have been generated for each patient to comparatively evaluate the dosimetric status of both techniques and all the patients received 7-field IMRT. Results: Dose-comparative evaluation of two techniques revealed the superiority of IMRT technique with statistically significantly lower femoral head doses along with reduced critical organ dose-volume parameters of bladder V60 (the volume receiving 60 Gy) and rectal V40 (the volume receiving 40 Gy) and V60. Conclusion: It can be concluded that IMRT is an effective definitive management tool for prostate cancer with improved critical organ sparing and excellent dose homogenization in target organs of prostate and seminal vesicles. Turkish Anahtar Kelimeler: Prostat kanseri, YART, 3-B Konformal RT Amac: Bu dozimetrik calismanin amaci 7-alan Yogunluk Ayarli Radyoterapi (YART) ve 3-Boyutlu 4-Alan Konformal Radyoterapi (3BKRT)'nin hedef doz homojenitesi ve kritik organ dozlarinin karsilastirilmasidir. Gerec ve Yontemler: Gulhane Askeri Tip Fakultesi Radyasyon Onkolojisi Anabilim Dali'nda Ocak 2009 ve Aralik 2009 yillari arasinda dusuk ve orta riskli prostat kanseri tanisiyla tedavi edilen 20 hasta bu calismaya dahil edildi. 7-alan Yogunluk Ayarli Radyoterapi (YART) ve 3BKRT'nin her ikisi icin ayri iki dozimetrik plan 7-alan YART uygulanan tum hastalari ve her iki teknigin dozimetrik durumunu degerlendirmek icin duzenlendi. Bulgular: Iki teknigin doz karsilastirmali degerlendirilmesi YART tekniginin istatistiksel olarak belirgin oranda dusuk femur basi dozlari ile azalmis mesane V60( 60 Gy alan volum) ve rektal V40 ( 40 Gy alan volum) kritik organ doz volum parametreleriyle ustunlugunu gosterdi. Sonuc: Sonuc olarak YART gelismis kritik organ koruma ve hedef organlar olan prostat ve seminal vezikullerin mukemmel doz homojenizasyonuyla prostat kanserinde etkili ve kuratif bir tedavi aracidir.
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