[Genotoxic and radioprotective properties of 2,5-diphenyloxazole and its derivatives on mice DNA structure in vivo].

: The effects of 2,5-diphenyloxazole ad its derivatives suggested as nontraditional radioprotectors on mice spleen DNA structure were studied. The effects of these compounds were studied on intraperitoneal injection with and without subsequent X-ray exposure of mice to a dose of 12 cGy. The formation of double-strand breaks and DNA conformation change (by adsorption on NC filters) were recorded. A genotoxic effect of 2,5-diphenyloxazole and its derivatives, a nonlinearity of their dose-response relationships and different effects depending on the substance concentration were found. Some of the compounds exhibited radioprotective properties in certain concentration.