Corneoxenometry: A Bioassay Exploring Skin Barrier Breaching

Some specific chemical compounds called penetration enhancers breach the skin barrier function after topical applications. It is important to predict the severity of alteration of the skin permeability barrier function. Corneoxenometry was designed as an ex vivo bioassay predicting on human stratum corneum the efficacy and the potential noxious effects of xenobiotics. The test substrate is a cyanoacrylate skin surface stripping harvested from normal or altered skin. Dose-response effects are conveniently tested while avoiding any skin hazards.