Forced expression of heat-shock protein 70 increases the secretion of Hsp70 and provides protection against tumour growth.

Prostate cancer is the second leading cause of cancer death in men in the United States, exceeded only by lung cancer. The American Cancer Society estimates that 28 900 men in the United States will die of prostate cancer in the year 2003. Currently, for patients with early stage, organ confined disease, there are well-defined treatment options, including radical prostatectomy, radiation therapy, or watchful waiting. However, no definitive treatments are available for advanced or recurrent disease. It is known that tumour regression can be achieved with androgen blockade; however, disease usually recurs within 1–2 years, leading to significant morbidity and mortality (Mahler and Denis, 1992).