Multivalent presentation of a hydrolytically stable GM3 lactone mimetic as modulator of melanoma cells motility and adhesion

Abstract A hydrolytically stable mimetic of the tumour antigen GM 3 lactone is used to decorate multivalent scaffolds. Two of them positively interfere on melanoma cell adhesion, migration and resistance to apoptosis (anoikis). Notably, their ability to hamper melanoma-cells adhesion and reduce the metastatic potential is enhanced when the two scaffolds, presenting a different shape, are used in combination.