Curcumin entrapped hyaluronan containing niosome: Preparation, characterization and in vitro/in vivo evaluation

AbstractCurcumin, a natural polyphenolic compound, has numerous pharmacological activities; while it faces several bioavailability problems, due to its poor solubility and stability. So, many nanostructures have been designed to overcome these drawbacks. The aim of this study was to prepare a polymeric niosomal structure by incorporating hyaluronan to improve curcumin efficiencies. Hyaluronan containing niosomes were prepared by thin film hydration medium with slight modifications. In the formulation of hyaluronan containing niosomes size and zeta potential studies, Atomic Force Microscopy (AFM), Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), Differential Scanning Calorimetry (DSC), X-Ray Diffraction (XRD), in-vitro release test, DPPH antioxidant assay and in- vivo anti-inflammatory test were investigated. The results showed that hyaluronan containing niosomes were 249.83 ± 6.38 nm and the entrapment of curcumin was 98.28 ± 0.278% (w/w). In addition, the shape of the hyalurona...