1,3-Bis(5 1 -methyl-4 1 -phenyl-2 1 -thiazolylimino)isoindoline

Abstract: A new sterically hindered isoindoline-based 1,3-bis(5 1 -methyl-4 1 -phenyl-2 1 -thiazolylimino)isoindoline( 1 ) was synthesized by fusion method with satisfyingly good yield. The structure of the newlysynthesized compound was identified by FT-IR, UV-Vis, 1 H-NMR, 13 C-NMR and X-ray analysis. Keywords: isoindoline-based ligand; pincer ligand; N,S-donor ligand; solvent-free conditions 1. Introduction The tridentate bis(arylimino)isoindolines (BAI) belong to the class of pincer type ligands.They are considered potent metal chelators and their coordination chemistry is extensively studied aswell. The ligand family originates from diiminoisoindolines and phthalocyanines that are buildingblocks of supramolecular architectures. It has been proven in a couple of biological studies that theymay possess antiproliferative activity and they can act as diuretic or blood pressure regulator agents [1].BAI with thiazole arms can add an extra function to transition metal complexes they coordinate to.Metal ions such as Cu, Fe, Mn, Co, Ni, etc. approach the N atom of the thiazole, while conditions maybe altered in order to achieve S-coordination for Pd (or Pt) [2].Bulky aliphatic or aromatic functional groups on the thiazole arm can easily block homolepticcomplex formation that is characteristic for isoindoline complexes [1]. This can create an advantageoussituation for cyclometallation [3] or intramolecular oxidative CH bond (benzylic and/or aromatic)activation reactions via peroxo or high valent oxo species [4].