Role of Extracellular Traps Promoted by Intestinal Parasites. Relationship with Virulence

NETosis is a form of programmed cell death in neutrophils characterized by the release of extracellular DNA traps (NET) composed of DNA associated with histones, granule enzymes and antimicrobial peptides. This mechanism of innate immunity has been linked to cell defense against different pathogens. In case of bacteria, NETosis has been directly associated with virulence, suggesting that its formation could depend on the pathogen’s ability to cause tissue damage. Moreover, NET formation can contribute to tissue destruction by promoting local inflammation and coagulation when exacerbated.