Differential effects of Renografin-76 on the ischemic and nonischemic myocardium.

Abstract The effects of intracoronary diatrizoate meglumine and diatrizoate sodium (Renografin-76) on regional contraction were examined in the normal coronary circulation and during partial (50 percent) coronary occlusion in 11 dogs using strain and length gauges. Intracoronary injections of Renografin-76 (1.5 cc) (1,690 mosM/liter; 0.19 mEq Na/ml), equiosmolar dextrose solution and 0.19 mEq Na + /ml saline solution were made randomly. Renografin-76 caused a decrease in preejection tension to 87.4 ± 4.3 percent (p