Value of fecal tumor M2 pyruvate kinase in colorectal adenoma detection

Objective To estimate the value of fecal tumor M2-PK in the detection of colorectal adenoma and to evaluate its potential as a screening tool for colorectal adenoma. Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect the fecal tumor M2-PK in stool samples of 65 patients with colorectal adenoma and 25 controls.At the same time, the peripheral blood tumor markers such as carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9, CA24-2 and fecal occult blood test (FOBT) were detected in the colorectal adenoma group. Results The detection value of fecal tumor M2-PK in the colorectal adenoma group showed a significant increase, compared with the control group((6.033±4.123) U/ml vs.(2.782±1.464) U/ml, t=-3.839, P=0.000). The highest detection value was found in the group where the diameter of adenoma was greater than or equal to 2 cm ((8.775±6.548) U/ml, t=9.635, P=0.034). The larger the diameter of adenoma, the higher the positive rate of fecal tumor M2-PK (85.7% vs.41.7% vs.29.6%, χ2=11.977, P=0.003). In the colorectal adenoma group, The positive detection rate of fecal tumor M2-PK was significantly higher than that of CEA, CA19-9, CA24-2 and FOBT (46.2% vs.6.2% vs.1.5% vs.1.5% vs.27.7%, ? 2=76.607, P=0.000). Conclusion Fecal tumor M2 pyruvate kinase has a good clinical value in the diagnosis of colorectal adenoma. Key words: Fecal tumor M2 pyruvate kinase; Colorectal adenoma; Diagnostic test