Influences of ozone on open-field behavior, passiveavoidance response, muscarinic receptors and LPO in mice

Young mice were exposed to an ozone environment from 20:00 to 08:00 for 30d. At 08:00,the content of ozone resulted from ultra-violet lamp was 0.9 ppm. Scopolamine(Scop 0.1mg·kg-1)was given ip 15 min before training in stepthrough and step-down tests or the first behavioral test in open field. The behavior and memory in mice were not influenced by ozone. However the effects of Scop on open-field behavior and avoidance memory were respectively less and more sensitive than those in normal mice. The binding slies of[3H]QNB increased in the frontal cortex and hippocampus,but decreased in the striatum region in the mice treated with ozone. The concentrations of lipid peroxidation measured by thiobarbituric acid in the mice exposed to ozone reduced 47%in whole brain and 46% in the frontal cortex.