Synthesis of New β-Trifluoromethyl Containing GABA and β-Fluoromethyl Containing N-Benzylpyrrolidinones.

Abstract A whole series of 3-(mono-, di-, trifluoro)methyl-substituted N -benzylpyrrolidinones 5a – c was synthesized by deoxyfluorination of corresponding 3-functionalized N -benzylpyrrolidinones. New β-trifluoromethyl containing GABA 4a was obtained in two alternative ways: by successive hydrolysis and hydrogenolysis of 3-trifluoromethyl N -benzylpyrrolidinone 5a and from trifluoroacetone as starting compound.