Enprofylline ‐ Effects of a New Bronchodilating Xanthine Derivative in Asthmatic Patients
1983
The bronchodilating effect of two doses of peroral enproffylline was compared with Placebo in 24 asthmatic patients, Enprofylline produced significantly greater bronchodilatation than placebo, A dose of 2 mg/kg b.wt. and 4 mg/kg b.wt. caused a mean maximal increase in FEV1 of 26% and 35%, respectively. The degree and the incidence of headache and nausea were estimated by means of a scoring system. Dose-related effects on both parameters observed. Other side effects were negligible. In seven patients the means plasma half-life of enprofylline was found to be 113 min. It is suggested that enprofylline should be studied further in Patients suffering from obstructive lung disease.
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