TUMOR OF THE TUBER CINEREUM WITH PRECOCIOUS PUBERTY: CASE REPORT WITH HORMONE ASSAYS

ABSTRACT The report is presented of a boy with precocious puberty as well as petit-mal and grand-mal epilepsy. Urinary titers of follicle stimulating hormone and interstitial-cell stimulating hormone were abnormally high. The urinary output of 17-ketosteroids, determined repeatedly, was never found to be elevated. A deep-seated central lesion in the brain was diagnosed by electroencephalography, but was not revealed by air encephalography on repeated occasions. At necropsy a hamartoma, 1.5 cm. in diameter, was identified in the tuber cinereum.