Formulation and Evaluation of Gastroretentive Floating Tablets of Quetiapine Fumarate.

The aim of the present investigation was to develop and evaluate gastroretentive drug delivery system (GRDDS) of Quetiapine Fumarate using a combination of hydrophilic polymers (HPMC K100M, HPMC K15M), natural gums (Guar gum, Xanthan gum and Karaya gum) and effervescent substances (sodium bicarbonate and citric acid). Floating tablets were prepared by direct compression method and were evaluated for physical characteristics such as hardness, thickness, friability, drug content and floating properties. The optimized formula Q13 showed better sustained drug release and also had good floating properties, it has shown zero order release with R