Применение газовой хроматомасс-спектрометрии для терапевтического лекарственного мониторинга вальпроевой кислоты

We have developed a new method for the quantitative determination of valproic acids based on gas chromatography with mass spectrometric detection of three ion fragments of a parent molecule with m / z = 73, 102, and 115. The proposed technique has been used to solve the tasks of anticonvulsant therapeutic drug monitoring and applied to determining individual pharmacokinetic characteristics of patients at the Research Center of Neurology of the Russian Academy of Medical Science with respect to valproic acid.