Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in Retinal Pigment Epithelium

Da Sun,Rebecca M. Schur,Avery E. Sears,Songqi Gao,Wenyu Sun,Amirreza Naderi,Timothy S. Kern,Krzysztof Palczewski,Zheng Rong Lu

Stable Retinoid Analogue Targeted Dual pH-Sensitive Smart Lipid ECO/pDNA Nanoparticles for Specific Gene Delivery in Retinal Pigment Epithelium

2020

Da Sun
Rebecca M. Schur
Avery E. Sears
Songqi Gao
Wenyu Sun
Amirreza Naderi
Timothy S. Kern
Krzysztof Palczewski
Zheng Rong Lu

Dysfunctions caused by gene mutations in the retinal pigment epithelium (RPE) lead to retinal degeneration, visual function loss, and even blindness. RPE-specific gene replacement therapy holds gre...

Keywords:

Cell biology
Gene delivery
Retinoid
Nanoparticle
Retinal pigment epithelium
Chemistry
gene mutation
visual function
Blindness
Retinal degeneration
Gene replacement therapy

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