Spindle Cell Squamous Cell Carcinoma of The Larynx: A Report of Three Cases

Spindle cell squamous cell carcinoma (SCSCC) is a rare malignant tumor, which involves both squamous cell carcinoma and sarcomatoid proliferation. It remains uncommon in the larynx and represents only 1 % of SCSCC of the head and neck. This tumor still poses diagnostic and therapeutic challenges. In the present report, three cases of laryngeal SCSCC were investigated; their clinical, pathological findings, treatment and outcomes are described. The patients were smoker men aged 50, 66 and 66 years old respectively. Dysphonia was the mean symptom. The tumor involves the vocal cord in all cases. The patient underwent laryngectomy with bilateral neck dissection. Histological examination confirmed the diagnostic of SCSCC. One case showed basaloid squamous cell carcinoma with sarcomatous transformation and osteosarcoma. Immunohistochemical analysis performed in one patient was positive for vimentin, SMA, PS100, focally for EMA and negative for keratin and P63.One case presented lymph nodes metastases and an adjuvant radiotherapy was preconised for this patient. All patients were well controlled after treatment and there was no recurrence during the following up.