Development of T-cell based reporter assay system to identify immunomodulators from herbal medicine

To evaluate immunomodulators from herbal medicines that affect the expression of IL-10 and TNF-α, we developed a cell-based high throughput screening system and tested 17 kinds of herbal medicine. We found that extracts of Coptidis Rhizoma can be used to stimulate TNF-α and IL-10 expression.