Relationship of highly sensitive C-reactive protein and lipid levels in adolescents with type 1 diabetes mellitus.

Karantza MV, Mittelman SD, Dorey F, Samie S, Kaiserman K,Halvorson M, Kaufman FR. Relationship of highly sensitive C-reactiveprotein and lipid levels in adolescents with type 1 diabetes mellitus.Pediatric Diabetes 2007Background: Atherosclerosis appears to begin in youth with type 1diabetes mellitus (T1DM). Highly sensitive C-reactive protein (hsCRP) isan independent marker of cardiovascular disease (CVD) risk in adults,but its relation to dyslipidemia and other CVD risk factors in adolescentswith T1DM is unknown.Objective: To study the association between lipids and hsCRP in youthwith T1DM.Design: Cross-sectional cohort.Methods: hsCRP and fasting lipids were measured in 74 patients withT1DM, mean age 16.2 2.62 yr, mean duration of diabetes 7.3 4.0 yr,and mean hemoglobin A1c (HbA1c) 8.5 1.3%. According to theAmerican Heart Association/Centers for Disease Control recommenda-tions, hsCRP values were divided into three groups: group 1: ,1.0 mg/L,low CVD risk; group 2: 1.0–3.0 mg/L, average CVD risk; and group 3:.3 mg/L, high CVD risk. Univariate linear regression between hsCRPand lipid and clinical parameters was used, with adjustment for age.Results: hsCRP was significantly associated with triglycerides (Tg),apoB, systolic blood pressure (SBP), and diastolic blood pressure (DBP).Subjects in the high CVD risk group had no further worsening of lipids orBP, except for a higher Tg level. ApoB, SBP, and DBP were elevated infemales with hsCRP 1 compared with the low-risk group, and high-density lipoprotein was decreased. In males, this difference was onlysignificant for SBP.Conclusions: Elevation of hsCRP to a level Tel: 323-669-4606;1.0 mg/L appears to beassociated with elevated lipid levels in adolescents with T1DM,particularly in females. hsCRP is a marker in youth that clusters withdyslipidemia and may indicate an increased CVD risk in youth withT1DM.