The Development and Implementation of LC/MS-Based Bioanalytical Methods for the Quantification of Protein Therapeutics in Drug Discovery
2013
The search to discover and develop viable therapies for the treatment of diseases continues to branch out in new directions and to improve and incorporate more efficient strategies to identify drug molecules in a cost-effective manner. Although proven treatments such as optimized small molecule drugs continue to provide an effective means for the management of certain medical conditions, alternatives such as engineered protein constructs have also been successful as therapeutic agents for treatment of a variety of diseases. Regardless of the type of drug molecule under consideration, optimized strategies and high-quality quantitative bioanalytical methods must be developed and applied throughout the drug discovery and development process in order to inform critical decisions during the selection and characterization of drug candidates.
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