A mutation in PTPN11 may drive leukemic transformation in a case of essential thrombocythemia

Belinda Guo,James Liang,Richard Allcock,Bob Mirzai,Bradley Augustson,Rebecca Howman,Kathryn Fuller,Wendy N. Erber

A mutation in PTPN11 may drive leukemic transformation in a case of essential thrombocythemia

2018

Belinda Guo
James Liang
Richard Allcock
Bob Mirzai
Bradley Augustson
Rebecca Howman
Kathryn Fuller
Wendy N. Erber

Myeloproliferative neoplasms (MPN) are a group of clonal hematopoietic stem cell disorders characterized by well-known driver mutations [1]. The mutational status of Janus kinase 2 (JAK2), calretic...

Keywords:

Cancer research
Essential thrombocythemia
Mutation
Medicine
PTPN11
disease progression
Immunology
Protein tyrosine phosphatase
Leukemia
Diabetes mellitus

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