The Study on the Antioxidative Activity of Resveratrol in Senescence-Accelerated Mouse Prone/8 (SAMP8)

In the present study, we examined resveratrol(RES)extracted from Polygonum cuspidatum on antioxidative effects in the senescence-accelerated mouse (SAM). We fed resveratrol to young adult SAM mice at doses of 25,50,100mg/(kg•bw) in their standard powder diet for 8-week. The body weight, organ weights and oxidation products of malondialdehyde (MDA) in the liver of the SAM were determined. The results showed that the SAM mice were no dose-related change in either body weight or organ weights, the amount of MDA declined distinctly in the mouse liver. In conclusion, resveratrol may have an antioxidant effect.