Risk Factors for Infection with Helicobacter pylori - a Study of Children in Rural Ethiopia

The public health impact of Helicobacter pylori (HP) infection is gradually becoming obvious, the bacterium now being implicated as an aetiologic agent in a variety of gastric diseases. Transmission routes still remain unknown, although single risk factors, such as domestic crowding (especially bed-sharing) in childhood and low parental socioeconomic status, have been pointed out in studies from developed countries. In an attempt to study the risk factors in a developing country, we performed a case control study of 242 randomly selected children aged 2-4 y in Butajira rural area in Ethiopia. Blood samples were drawn and a questionnaire administered. The total prevalence of IgG antibody to HP among the children in the region was 48% (116/242). Several risk factors such as: crowding, water, animals, sanitation, etc. correlated strongly to seropositivity in a univariate analysis. After controlling for possible confounding, independent predictors of seropositivity were: living in town (OR=2.15, p=0.001), inc...