RNome and Chromatin Dynamics

Epigenetic changes are central to the regulation of gene expression in eukaryotes. Different environmental and developmental cues bring about a change in total RNA pool that dictates cellular responses without changing the original genetic information. Interestingly, the epigenetic machinery is itself regulated by several non-coding RNAs (ncRNAs). Adding to this intricate network are the recently discovered RNA modifications. Termed as “epitranscriptomics,” these RNA modifications significantly impact RNA localization and function by changing its structure or ability to bind with different biochemical partners. This chapter explores different epigenetic mechanisms (such as DNA and histone modifications and chromatin remodeling), reciprocal relationship between ncRNAs, and chromatic dynamics as well as RNA modifications and their role in gene regulation.