Copper‐Catalyzed C(sp2)–C(sp3) Cross‐Dehydrogenative Coupling of Quinones with Cyclic Alkanes: One‐Step Access to Parvaquone and its Analogs

A copper-catalyzed direct cross-coupling reaction of quinones with cycloalkanes in the presence of tert-butyl hydro peroxide was developed. This methodology allows the direct installation of cycloalkyl groups with medium- and large-sized rings on 1,4-naphthoquinones, anthracene-1,4-dione, or 1,4-benzoquinones. Based on this new protocol, the one-pot synthesis of the antimalarial drug, parvaquone, was achieved.