LB-005 Unruptured arteriovenous malformation intervention rate is inversely correlated with ruptured AVM discharge incidence

Introduction The 2013 ARUBA trial concluded that medical management alone is superior to medical management with interventional therapy for patients with unruptured brain arteriovenous malformations. Objective To analyze AVM treatment and epidemiologic response to the ARUBA trial. Methods National Inpatient Sample was reviewed from 2003 to 2017, ruptured and unruptured AVMs were identified (rAVM, uAVM). Periods before and after ARUBA defined as 2010–2013 and 2014–2017. Multivariable logistic regression identified correlates to intervention likelihood. Yearly intervention rate (YIR, #interventions/#AVM discharges) and yearly rAVM incidence (YRR, #rAVM/#AVM discharges) were calculated. Segmented regression (SR) identified significant change-points and fitted segmented linear models for YIR and YRR. Average annual percent change (AAPC) was estimated as the weighted sum of segmented model slopes. Pearson coefficients (PC) examined correlation between YIR and YRR. RStudio performed statistics. Results 90,296 AVM discharges were identified from 2010–2017. AVM discharges were seen at smaller, non-academic hospitals following ARUBA (p Conclusion Following ARUBA, there has been a stark decrease in interventions for uAVMs. Nationwide rAVM discharge incidence is inversely correlated with uAVM intervention rate. Less uAVM interventions may lead to a substantial increase in AVM rupture incidence. Disclosures D. McCarthy: None. E. Luther: None. B. Gross: None. R. Starke: None.