The first example of Michael addition catalysed by modified Mg–Al hydrotalcite
1999
Selective 1,4-additions (Michael reactions) on methyl vinyl ketone, methyl acrylate, simple and substituted chalcones by donors such as nitroalkane, malononitrile, diethylmalonate, cyanoacetamide and thiols were catalysed by solid base, modified Mg-Al hydrotalcite as catalyst in quantitative yields in liquid phase under mild reaction conditions. Products of undesirable side reactions resulting from 1,2-addition, polymerisation and bis-addition are not observed. The work-up procedure is simplified by simple filtration with the use of solid bases.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
22
References
128
Citations
NaN
KQI