Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series

Anna A. Nazarova,Kseniya N. Sedenkova,Dmitry S. Karlov,Mstislav I. Lavrov,Yuri K. Grishin,Tamara S. Kuznetsova,V. L. Zamoyski,Vladimir Viktorovich Grigoriev,Elena B. Averina,Vladimir A. Palyulin

Bivalent AMPA receptor positive allosteric modulators of the bis(pyrimidine) series

2019

Anna A. Nazarova
Kseniya N. Sedenkova
Dmitry S. Karlov
Mstislav I. Lavrov
Yuri K. Grishin
Tamara S. Kuznetsova
V. L. Zamoyski
Vladimir Viktorovich Grigoriev
Elena B. Averina
Vladimir A. Palyulin

The first example of a novel class of AMPA receptor positive allosteric modulators of the bis(pyrimidine) series having a hydroquinone linker has been obtained and showed a potency to increase kainate-induced currents at subnanomolar concentrations.

Keywords:

Linker
Bivalent (genetics)
Stereochemistry
Pyrimidine
Chemistry
Biochemistry
Hydroquinone
Allosteric regulation
Potency
AMPA receptor

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