Towards a neurobiological understanding of pain in neurofibromatosis type 1: mechanisms and implications for treatment

AbstractNeurofibromatosis type 1 (NF1) is the most common of a group of rare diseases known by the term, “Neurofibromatosis,” affecting 1 in 3000 to 4000 people. NF1 patients present with, among other disease complications, cafe au lait patches, skin fold freckling, Lisch nodules, orthopedic complic