A new technique of orthotopic en bloc transplantation of the porcine liver and duct-ligated pancreas

Abstract A new technique of transplanting porcine liver and pancreas en bloc in an orthotopic position is described. The pancreatic duct was ligated. Recipients were made diabetic either by total pancreatectomy or by intravenous administration of streptozotocin, (100 mg/kg body wt). Careful correction of electrolyte and fluid disturbances in recipient animals was mandatory before and after surgery. No rejection of either liver or pancreas grafts was seen. The endocrine function of the pancreatic grafts was adequate.