Number and Type of Blood Products are Negatively Associated With Outcomes Following Cardiac Surgery.

ABSTRACT Background The association between blood transfusion and adverse outcome is documented in cardiac surgery. However, the incremental significance of each unit transfused, whether red blood cell (RBC) or non-RBC, is uncertain. This study examined the relationship of patient outcomes with type and number of blood product units transfused. Methods Statewide data from adult cardiac surgery patients were included (N=24,082). Relationship with blood transfusion was assessed for morbidity and 30-day mortality using total number of RBC and non-RBC units transfused, specific type of non-RBC units, and different combinations of transfusion (only RBC, only non-RBC, RBC+non-RBC). Multivariable logistic regressions examined these associations. Results Median age was 66 years (30% female) with 51% of patients transfused (31%-66% across hospitals). Risk-adjusted analyses found each blood product unit associated with 9%, 7%, and 4% greater odds for 30-day mortality, major morbidity, and minor morbidity (all P Conclusions Independent of center variability on transfusion methods, each additional unit transfused was associated with increased odds for complications, with RBC transfusion carrying greater risk compared to non-RBC. Comprehensive evidence-based clinical approaches and coordination are needed to guide each blood transfusion event following cardiac surgery.