Safety and efficacy of Certolizumab Pegol in a real-life cohort of patients with Psoriasis and Psoriatic Arthritis.

AbstractBackground: Aim of this observational study was to assess safety and efficacy of Certolizumab Pegol(CZP) in a real-life cohort of patients affected by psoriasis(PsO) and psoriatic arthritis(PsA), who had an inadequate response to previous systemic immunosuppressive treatments, with a follow-up of 24 weeks.Materials and methods: Twelve patients with PsO and PsA, referring to our Dermatology/Rheumatology combined outpatient clinic, were enrolled.Primary endpoints were safety and efficacy of CZP, defined as statistically significant improvement of DAPSA, clinical DAPSA and PASI.Secondary endpoints were validated clinical and laboratory measures and patient-reported outcomes.Results: CZP injections were well-tolerated.We observed a rapid and significant improvement in all primary endpoints, in the 24-week treatment period of the study.We described positive effects of CZP in several domains, including joint and skin involvement, pain, patient and physician global assessment, physical function, and heal...