Reply to Yamada et al.: Questions and answers to the validity of the doubly labeled water method in high-fat and sucrose-feeding mice irrespective of obesity proneness

reply: we have reported recently that 1 ) mice fed a diet rich in saturated fat and sugar (HFS), irrespective of whether they are obesity prone or resistant, have an overestimated rate of CO2 production (rCO2) when calculated by the doubly labeled water (DLW) method compared with actual gas exchange