Use of Modeling and Simulations to Determine Raltegravir Dosing in Neonates: A Model for Safely and Efficiently Determining Appropriate Neonatal Dosing Regimens

Background:Population modeling and simulations can be used to facilitate the conduct of phase I studies to develop safe and effective dosing regimens in neonates.Setting:P1110 is an international, multicenter trial to determine safe and effective raltegravir doses in neonates at risk for HIV infecti