Compositions 5HT2C receptor modulator and methods of use.

Composition comprising phentermine and a selective 5HT-receptor agonist 2C, wherein said selective 5HT-receptor agonist 2C is selected from (R) -1- (5-chloro-2-fluoro-phenyl) -2-methylpiperazine, compounds of formula (I) and salts, solvates and hydrates thereof: ** (See formula) ** in which: R1 is H or C1-8 alkyl; R2 is C1-8 alkyl, -CH2-O-C1-8 alkyl, -C (= O) -O-C1-8 alkyl, -C (= O) -NH-C1-8 alkyl, OH or CH2OH; R2a is H; or R2 and R2a together form -CH2-CH2-; R3 and R4 are each independently H, halogen, perhaloalkyl, CN, OR5, SR5, NHR5, N (R5) 2, OH, aryl or heteroaryl, wherein said aryl is optionally substituted with up to two substituents selected from C1- 8, halogen, perhaloalkyl, and alkoxy, and said heteroaryl is optionally substituted with up to two substituents selected from halogen and C1-8 alkyl; or R3 and R4 together with the atoms to which they are attached form a heterocyclic ring of 5 or 6 membered ring having one O atom; each R5 is independently C1-8 alkyl, C1-8 alkenyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl or perhaloalkyl, or allyl; and R6 is H or C1-8alkyl.