Platelet-rich plasma therapy in the treatment of diseases associated with orthopedic injuries.

: PRP is an autologous platelet concentrate prepared from the whole blood that is activated to release growth factors and cytokines and has been shown to have the potential capacity to reduce inflammation and improve tissue anabolism for regeneration.The use of platelet-rich plasma (PRP) provides a potential for repair due to its abundant growth factors and cytokines, which are key in initiating and modulating regenerative microenvironments for soft and hard tissues. Among outpatient, orthopedic injuries are common and include bone defects, ligament injury, enthesopathy, musculoskeletal injury, peripheral nerve injury, chronic nonhealing wounds, articular cartilage lesions and osteoarthritis, which are caused by trauma, sport-related or orther types of trauma or tumor resection. Surgical intervention is often required to treat these injuries. However, for numerous reasons regarding limited regeneration capacity and insufficient blood supply of the defect region, these treatments commonly result in unsatisfactory outcomes, and follow-up treatment is challenging. The aim of the present review is to explore future research in the field of PRP therapy in the treatment of diseases associated with orthopedic injuries.