Effect of ATM–111 (G>A) Polymorphism on Cancer Risk: A Meta-Analysis

Objective: To assess the relationship between the ataxia telangiectasia mutated (ATM) gene–111 (G>A) polymorphism and cancer risk. Methods: The PubMed, EMBASE, Web of Science, and China National Knowledge Infrastructure databases were searched comprehensively. A total of 16 case–control studies with 12,273 cases and 13,046 controls were included in this meta-analysis; 12 of them were from the Chinese population. Five studies assessed smoking effects, including 3038 smokers and 1003 nonsmokers. Odds ratio (OR) was determined by using a genetic model-free approach. Heterogeneity was quantified by I2 statistics. Publication bias was also evaluated. Results: The recessive model (AA vs. AG + GG) was suggested as the most appropriate genetic model. After elimination of heterogeneity, it was found that the ATM–111 (G>A) AA genotype is significantly associated with increased susceptibility to overall cancer risk in a fixed effects model (OR = 1.09; 95% CI = 1.03–1.15; p < 0.01; I2 < 0.01). In the subgroup analysi...