Sulphonylpyrrole hydrochloride as histone deacetylase inhibitors

2006 
It is of formula I, in which, R1, R2, R3, R4, R5, compounds and salts thereof have the meanings R6 and R7 are shown in the specification are effective HDAC inhibitors of the novel. More particularly, the present invention, (E) - (E) -N- hydroxy -3- (1- [4 - (([2- (1H- indol-2-yl) - ethyl] - methyl - amino ) - methyl) - benzenesulfonyl]-1H-pyrrol-3-yl) - acrylamide, (E) -3- [1- (4- dimethylaminomethyl - benzenesulfonyl)-1H-pyrrol-3-yl] -N - hydroxy - acrylamide, and (E)-N-hydroxy-3- [1- (5-pyridin-2-yl - thiophene-2-sulfonyl)-1H-pyrrol-3-yl] - compounds selected from acrylamide refers a salt with hydrochloric acid, their hydrates as well as crystalline forms of these salts and hydrates.
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