Prediction of Infarct Core and Salvageable Ischemic Tissue Volumes by Analyzing Apparent Diffusion Coefficient Without Intravenous Contrast Material

Rationale and Objectives To investigate whether baseline apparent diffusion coefficient (ADC) maps can be employed to predict both infarct core and salvageable ischemic tissue volumes in acute ischemic stroke. Materials and Methods An automated image analysis system based on baseline ADC maps was tested against 30 patients with acute ischemic stroke of anterior circulation to predict both infarct core and salvageable ischemic tissue volumes. The predicted infarct core and predicted salvageable ischemic tissue were quantitatively and qualitatively compared with follow-up imaging data in recanalization and no recanalization groups, respectively. Direct comparisons with perfusion- and diffusion- weighted magnetic resonance imaging measures were also made. Wilcoxon signed-rank test, Spearman rank correlation, and Bland-Altman plots were performed. Results In the recanalization group, the predicted infarct core volume was significantly correlated with the final infarct volume ( r = 0. 868, P r = 0.955, P r = 0.918, P Conclusion The proposed ADC based approach may be a feasible and practical tool to predict the volumes of infarct core and salvageable ischemic tissue without intravenous contrast media–enhanced perfusion-weighted imaging at baseline.