氯化亚铁四水合物/TBHP催化氧化取代乙苯反应的研究 Ferrous Chloride Tetrahydrate/TBHP Catalyzed Oxidation of Substituted Ethylbenzenes

苯乙酮及其衍生物作为一类重要的有机化工中间体，广泛用于香料的生产中和塑料的增塑剂等。本文通过在常压、水作为溶剂条件下，过氧化叔丁醇(TBHP)和氯化亚铁四水合物结合催化氧化取代乙苯合成了一系列苯乙酮类衍生物，确定了催化取代乙苯氧化合成苯乙酮类衍生物的最优反应条件为：取代乙苯1 mmol，1 mol% FeCl2·4H2O，10当量的TBHP，2 mL水，反应温度为80℃，反应时间为12 h。该方法具有选择性高，反应条件温和，催化剂廉价易得，分离简单，底物适用范围广等优点。 Acetophenone and its derivatives as important organic intermediates have been widely used in the production of perfume and plastic plasticizer. In this paper, a series of acetophenone derivatives were synthesized by tert-butyl hydroperoxide (TBHP) and ferrous chloride tetrahydrate combined catalytic oxidation of substituted ethylbenzene in the aqueous phase at atmospheric pressure. The optimal reaction conditions were as follow: 1 mol% FeCl2·4H2O, 10 equivalents of TBHP, 1 mmol ethylbenzene, 2 mL H2O, 80˚C reaction temperature, 12 h reaction time. The method has many advantages of high selectivity, mild reaction conditions, cheap and readily available catalyst, simple separation, and a wide scope of substrates.