Determinants of severe chronic fatigue among epithelial ovarian cancer survivors: A GINECO VIVROVAIRE study.

5573Background: Vivrovaire was a large case-control study comparing patients reported outcomes (PROs) between 318 Epithelial Ovarian Cancer Survivors (EOCS) without relapse ≥3 years after 1st line treatment and age matched controls. Severe chronic fatigue (SCF), the main end point, (26% of EOCS) was one of the most frequent reported late side effects (Joly et al, abstr 940PD, ESMO 2017). The aim of this exploratory study was to assess determinants of SCF among EOCS. Methods: EOCS were recruited in 27 centers. Patients filled-in PROs questionnaires: quality of life, neurotoxicity and fatigue (FACT-G, FACT-O, FACT/GOG-Ntx, FACT-F), anxiety/depression (HADS), sleep disturbance (ISI) and physical activity (IPAQ). SCF was defined as FACT-F score < 37. Variables associated with SCF (p < 0.01) were included in a multivariate logistic regression. Results: EOCS were: Median age 65[20-86] years, high level of education (52%), FIGO stage I/II (50%), III/IV (48%). Histologic subtypes were: serous 49%, endometrioid 15...